منابع مشابه
Hepcidin assays: ironing out some details.
I ron is the fourth most common element in the earth’s crust and the most abundant transition metal in the human body. It is an essential element required for growth and survival. Maintaining the correct iron balance is crucial for health. All living organisms evolved sophisticated mechanisms to maintain appropriate iron levels in their cells and within their body. It was shown recently that th...
متن کاملHepcidin regulation: ironing out the details.
Hepcidin is a peptide hormone secreted by the liver that plays a central role in the regulation of iron homeostasis. Increased hepcidin levels result in anemia while decreased expression is the causative feature in most primary iron overload diseases. Mutations in hemochromatosis type 2 (HFE2), which encodes the protein hemojuvelin (HJV), result in the absence of hepcidin and an early-onset for...
متن کاملIroning out the role of hepcidin in infection.
Shortly after hepcidin was identified and isolated but before it was elucidated as a master regulator of iron metabolism, it became clear that inflammation was one of the principal regulators of hepcidin. Since then, it has been thought that hepcidin may protect against some infections. Proliferation in some so-called siderophilic bacteria is limited by access to iron, whereas other bacteria ar...
متن کاملIroning out cancer.
New insights into the roles of proteins that regulate cellular iron in cancer growth, angiogenesis, and metastasis have recently emerged. Discoveries of the roles of ferroportin, hepcidin, lipocalin 2, and members of the six transmembrane epithelial antigen of the prostate (STEAP) and iron regulatory protein (IRP) families in cancer have provided specificity and molecular definition to the role...
متن کاملIroning out Ferroportin.
Maintaining physiologic iron concentrations in tissues is critical for metabolism and host defense. Iron absorption in the duodenum, recycling of iron from senescent erythrocytes, and iron mobilization from storage in macrophages and hepatocytes constitute the major iron flows into plasma for distribution to tissues, predominantly for erythropoiesis. All iron transfer to plasma occurs through t...
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ژورنال
عنوان ژورنال: Clinical Journal of the American Society of Nephrology
سال: 2009
ISSN: 1555-9041,1555-905X
DOI: 10.2215/cjn.02690409